Anisomycin downregulates gap-junctional intercellular communication via the p38 MAP-kinase pathway

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Anisomycin downregulates gap-junctional intercellular communication via the p38 MAP-kinase pathway.

Phosphorylation of connexin 43 (Cx43) molecules (e.g. by extracellular signal-regulated kinase) leads to reductions in gap-junctional intercellular communication (GJIC). GJIC levels also appear to be lower in the presence of p38 mitogen-activated protein (MAP) kinase, for unknown reasons. In this study, we used assays of the recovery of fluorescence by photobleached WB-F344 cells to demonstrate...

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Gap junctions are comprised of proteinaceous, plasma membrane channels that link the interiors of adjacent cells and permit cells to directly exchange small (< 1,000 Daltons) molecules and ions. This exchange, termed gap junctional intercellular communication (GJIC), appears to be involved in growth regulation. Growth controlling factors may pass between cells through the junctions. The loss of...

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ژورنال

عنوان ژورنال: Journal of Cell Science

سال: 2004

ISSN: 1477-9137,0021-9533

DOI: 10.1242/jcs.01056